Does low magnesium affect aging?

Magnesium is one of the most important minerals in the human body. It activates hundreds of enzymes involved in all major biochemical and metabolic processes in cells. It is important for DNA and protein synthesis, energy metabolism of cells, cell division and growth, conduction of nerve impulses, contraction of skeletal and heart muscle, growth and mineralization of bones, and immune system function. Its deficiency will also affect aging, and aging will affect its level.

Why are we low in magnesium?

The recommended daily dose is set at 375 mg. Unfortunately, most of us simply cannot reach this value with the help of diet. One of the main reasons why we are low in magnesium in our food is the fact that agricultural soils are becoming increasingly poor in essential minerals and magnesium is being lost in the processing of grains, food and even cooking. So even with a balanced diet, you may not have the necessary amount of magnesium.


Approximately 50-60% of the body's total magnesium content is stored in the bones.

Magnesium and aging

Unfortunately, the level of magnesium in the body decreases with age. In addition to the low amount of magnesium in food, it also contributes to a decrease in magnesium absorption in the intestines. With age, there is also more excretion of magnesium in the urine due to poorer kidney function. Low magnesium can be difficult to detect as it can easily be confused with common signs of aging, for example. So what does low levels do in the body with regards to aging?


Change in intestinal microflora

The composition of the gut microbiota gradually changes during aging, leading to an overall reduction in gut diversity. The imbalance of the intestinal microbiota and disruption of the intestinal microbiome further affects the physiological processes in the body. Specifically, it can be a loss of the enzyme lactase, which can cause lactose intolerance. Analyzes of the intestinal microbiome have shown associations between the level of magnesium in the diet and the composition of the intestinal microbiota. Magnesium supplementation has been shown to increase the number of bacteria associated with gut health.


Limitation of autophagy, i.e. cell repair

Autophagy is a cellular process in which cells repair and recycle damaged cellular components. The body's ability to carry out this process decreases with age, which contributes to the accumulation of damaged cellular structures and parts. You can think of it as a kind of cellular debris inside a cell. So you probably understand that it's not exactly an ideal situation. Studies have shown that magnesium can help with this quite well. Low levels of dietary magnesium are associated with reduced autophagy, while magnesium supplementation can promote autophagy.


Autophagy eliminates pathological phenomena in cells.

Telomere shortening

You may have heard of them before. Telomeres are sections of DNA at the ends of chromosomes that shorten each time a cell divides. And so they get shorter with age. When telomeres reach a critical length, cell division stops. The main role of telomeres is to protect the chromosome. This is where magnesium plays an important role. It helps regulate the structure, integrity and function of telomeres as well as an enzyme that prevents telomere shortening. Research has shown that higher magnesium intake will help with longer telomeres. Thanks to magnesium, the telomeres can divide for a longer period of time and the cells live longer thanks to this.


Low levels of magnesium in older age will also affect intercellular communication, immunity, stem cells and overall cell division of various tissues or alter cell metabolism. However, it is not always easy to detect magnesium deficiency in the body. The level of magnesium is usually determined by measuring the total level in the blood serum, which reflects only a very small part of the body's magnesium content. Approximately 50-60% of the body's total magnesium content is stored in the bones and the rest is stored in the cells. Only less than 1% of body magnesium is found in serum. Therefore, serum values ​​often do not accurately reflect cellular magnesium status. These may be low even when serum levels are in the appropriate range. Another option for measuring magnesium levels in the body is a blood test, or its amount in the cells.


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