Blog

Vitamín D3: Všechno, co potřebujete vědět.

Spolu s hořčíkem tvoří nejvíce deficitní dvojici prvků v populaci napříč kontinenty. Hádáte správně, jde o vitamín D. I když je označován jako vitamín, v poslední době o něm odborníci stále častěji mluví spíše jako o hormonu. Je to proto, že má v těle na starost mnoho hormonálních funkcí. Nejčastěji se vyskytuje ve formě vitamínu D3 u živočichů, včetně lidí, a ve formě vitamínu D2 u rostlin. Kde a jak vitamín D vzniká Jde o jediný vitamín, který je tělo schopné si samo vyrobit. K jeho aktivaci je nutná změna jeho struktury. Ta probíhá ve dvou krocích nejprve v játrech a pak v ledvinách. Tělo vitamín D vyrábí syntézou cholesterolu. Reakci spustí pokožka vystavená UVB záření. K jeho tvorbě je nutná speciální vlnová délka slunečního záření, konkrétně 300 nm. Tato forma záření je u nás dostupná jen od dubna do října mezi 10. a 15. hodinou. Zdroje vitamínu D Nejvíce vitamínu D tedy získá tělo ze slunce. Některé zdroje uvádějí, že jde až o 90 % potřebné dávky. Možná jste nevěděli, že si organismus umí vitamín D uložit do zásoby na horší časy – konkrétně do tukových tkání a svalů. Co jste možná nevěděli, že si ho organismus umí uložit do zásoby, na horší časy do tukových tkání a do svalů. Dalším zdrojem kromě slunečního záření jsou pak potraviny bohaté na vitamín D, které pokryjí zbylých 10 %. Třetím zdrojem vitamínu D je pak kvalitní doplněk stravy. Jaké potraviny obsahují nejvíce vitamínu D Špatnou zprávou je, že z potravy se ho do těla nikdy nedostane dost. Ani potraviny s nejvyšším obsahem vitamín D3 nepokryjí denní dávku. I tak se ale hodí vědět, co do jídelníčku můžete zařadit. Nejvíce vitamínu D3 obsahují tučné ryby jako tuňák, losos, ale i sardinky. Najdete ho i ve vaječném žloutku, houbách nebo v mléce. Vitamín D3 je vhodné užívat s jídlem, které obsahuje tuk, kvůli lepšímu vstřebávání. Ať je to snídaně nebo oběd, tohle se vyplatí si pohlídat. Doporučená denní dávka vitamínu D Denní dávka vitamínu D je předmětem mnoha diskuzí a odborníci se na ní ne vždy shodnou. Množství vitamínu D je totiž dost individuální záležitost, která je závislá na mnoha faktorech. Dříve stanovená hodnota 600 IU jednotek nejspíš pro pokrytí potřeby nestačí. Ať už jste zastánci jedné, nebo druhé pravdy, při vyšších dávkách vitamínu D3 je dobré užívat i vitamín K2. Pomáhá bránit kalcifikaci cév, ke které by mohlo docházet v souvislosti s užíváním vyšších dávek vitamínu D3. A pozor! Vitamínem D3 je možné se také předávkovat. Co v těle vitamín D ovlivňuje? Tři nejvíce prozkoumané oblasti Zdravé kosti Vitamín D podporuje vstřebávání vápníku a reguluje množství fosforu v těle. Pomáhá kostem s jejich správnou mineralizací a vývojem. Dá se říct, že by vápník bez vitamínu D nemohl plnit svoji funkci. A nízké hladiny vápníku můžou vést od křehnutí kostí až například k osteoporóze - chronickému řídnutí kostí. Neprůstřelnou imunitu  Pro imunitu je vitamín D zásadní. Ovlivňuje totiž funkci té vrozené i získané. Hraje důležitou roli v regulaci zánětlivých procesů a aktivuje T-lymfocyty, buňky v první linii imunitního systému. Jak to dělá? Pomáhá buňkám rozpoznat a zlikvidovat škodlivé patogeny. V novějších výzkumech se také ukazuje, že by mohl pomáhat předcházet autoimunitním chorobám tím, že reguluje nadměrnou aktivitu imunitního systému. Podzimní deprese Nízké hladiny vitamínu D jsou také spojovány s možným výskytem sezónní - podzimní deprese. Jde o stav, který trvá několik měsíců. Podzimní proto, že nastupuje v čase, kdy ubývá slunečních paprsků a hladina vitamínu D se snižuje. Vypadá to, že jeho nízké hladiny ovlivňují hodnoty serotoninu, hormonu štěstí. Pokud ho má tělo málo, můžou nastupovat pocity smutku, podráždění až deprese.  Abychom ale skončili tohle vyprávění o vitamínu D na pozitivní vlně, pojdme se na závěr podívat na pár zajímavostí, které se do článku nevešly: Vitamínem D je možné se předávkovat. Hlavně při dlouhodobém užívání vyšších dávek. To pak vede k vysoké hladině vápníku v krvi a vápenatění cév. V mírnější formě se předávkování může projevit bolestí hlavy, nechutenstvím a nevolností. Schopnost těla syntetizovat vitamín D s věkem klesá. Proto mohou být starší lidé náchylnější na zlomeniny díky řídnutí kostí. Vitamín D je nejvíce deficitním prvkem v organismu. Odhaduje se, že až jedna miliarda lidí na světě trpí jeho nedostatkem. Hůře jsou na tom pak bohužel ženy a celkově státy s nízkým počtem slunečných dnů. Tmavší pokožka produkuje méně vitamínu D . Obsahuje totiž více melaninu, který působí jako přírodní ochrana proti UV záření a to snižuje schopnost syntézy vitamínu D. Vitamín D ovlivňuje více než 200 genů v těle. Má důležitou roli v mnoha biologických procesech, včetně už zmíněné imunity, růstu buněk nebo fungování nervového systému. Vyzkoušejte Flow kombinaci vitamínu D3 + K2 v biodostupných formách v MCT oleji pro správné vstřebání.👇 Zobrazit

Learn more

The Mushroom Picker's Guide: How Adaptogenic Mushrooms Affect Your Body and Mind

They say we are a nation of mushroom pickers. We set off into the forest with a basket and the hope that there will be fried food in the evening. We dry, fry, preserve. But that's not all there is to using mushrooms. According to the latest calculations by scientists from the Academy of Sciences, there are more than 6 million different types of mushrooms in the world. Edible, poisonous, medicinal, hallucinogenic and then the adaptogenic ones. You can find them in various dietary supplements and they have become very popular in the health world. What are adaptogenic mushrooms? Adaptogenic mushrooms contain substances that can help reduce the effects of stress on your body. These are not hallucinogenic or "magic" mushrooms. Adaptogens do not affect the mind or perception. In general, an adaptogen is a substance that increases the body's resistance to physical, biological, and chemical stress and helps support normal functioning when you are already under stress. How do adaptogens work? The body's response to stress is complex and involves multiple body systems, including the hypothalamic-pituitary-adrenal axis. The main function of this imaginary axis is the release of glucocorticoids - steroid-based hormones, including cortisol - the stress hormone. Glucocorticoids then activate the stress response. And this is where adaptogens come in. They act on the aforementioned hypothalamus-pituitary-adrenal axis by increasing resistance to stress, promoting stability and accelerating recovery from stress on a biochemical level. Hypothalamus - is the part of the brain that controls key functions such as body temperature, hunger, thirst and sleep. It also forms a link between the nervous system and the hormonal system, thereby influencing the functioning of many organs. The pituitary gland is a small gland in the lower part of the brain that produces hormones that affect growth, reproduction, metabolism and other important bodily functions. It plays an important role in the regulation of vital functions. Adrenal glands - glands with internal secretion of hormones found on the upper part of the kidney. Glucocorticoids - steroid-based hormones. Cortisol - a stress hormone that triggers stress reactions. Many mushrooms have anti-inflammatory effects or perhaps boost immunity. The term adaptogenic refers to the fact that the substances they contain can influence the body's response to stress. Cordyceps This medicinal mushroom has been used in China and Tibet for many years. It has a positive effect on chronic stress, supports the optimal function of the immune system, resistance to fatigue. It contains betaglucans and minerals such as sodium, potassium, calcium, magnesium, iron and zinc. In nature, you can find it as a parasite of one type of insect. But don't worry, you won't find this wild form in food supplements. Currently, the cordyceps mushroom is grown on mushroom farms, so no insects suffer. It has up to a hundred different species. The most researched and used species are Cordyceps sinensis or Chinese caterpillar and Cordyceps militaris - red caterpillar. Lion's mane The Czech translation gave this mushroom the name lion's mane, which it really resembles with fibers. The mushroom is widely used in gastronomy in Japan, Korea and China. In addition to supporting the nervous system, it also has a positive effect on digestion and overall vitality. And the large amount of bioactive substances makes it a great antioxidant. Why is it so beneficial? It supports the healthy development of the structure of neurons and the brain. Lion's mane also supports protective functions in the brain by reducing oxidative stress and abnormal immune signaling in the body. In addition, it can have a positive effect on gut health and gut microflora, which can contribute to overall well-being through the connection of the gut-brain axis. And finally, one interesting thing: it is possible to make 125 mg of extract from one gram of mushroom. Reishi You've probably already heard of her. She was a bit of a pioneer of mushrooms from the East. It earned the nickname "mushroom of immortality". Modern research on Reishi mushrooms emphasizes their benefits for supporting the immune system and rejuvenating processes in the body. Several preclinical studies have shown that it supports immune cell function and both innate and acquired immunity. Research also shows that it supports healthy mitochondrial function in the brain. Focus on concentration when choosing the right supplement. It is also important whether the extract is made only from the fruiting bodies of the mushrooms or also from the pods. As you probably already guessed, the best is a pure extract only from fruiting bodies that contain the most active substances. Of course, there are many more adaptogens. We were quite interested in them, so you can find them in some of our products. And for example, we also have Cordyceps separately in powder form in the pure substances section. You can easily prepare an adaptogenic coffee or smoothie. Cheers to health and well-being. Display Display Display Display

Learn more

Does low magnesium affect aging?

Magnesium is one of the most important minerals in the human body. It activates hundreds of enzymes involved in all major biochemical and metabolic processes in cells. It is important for DNA and protein synthesis, energy metabolism of cells, cell division and growth, conduction of nerve impulses, contraction of skeletal and heart muscle, growth and mineralization of bones, and immune system function. Its deficiency will also affect aging, and aging will affect its level. Why are we low in magnesium? The recommended daily dose is set at 375 mg. Unfortunately, most of us simply cannot reach this value with the help of diet. One of the main reasons why we are low in magnesium in our food is the fact that agricultural soils are becoming increasingly poor in essential minerals and magnesium is being lost in the processing of grains, food and even cooking. So even with a balanced diet, you may not have the necessary amount of magnesium. Approximately 50-60% of the body's total magnesium content is stored in the bones. Magnesium and aging Unfortunately, the level of magnesium in the body decreases with age. In addition to the low amount of magnesium in food, it also contributes to a decrease in magnesium absorption in the intestines. With age, there is also more excretion of magnesium in the urine due to poorer kidney function. Low magnesium can be difficult to detect as it can easily be confused with common signs of aging, for example. So what does low levels do in the body with regards to aging? Change in intestinal microflora The composition of the gut microbiota gradually changes during aging, leading to an overall reduction in gut diversity. The imbalance of the intestinal microbiota and disruption of the intestinal microbiome further affects the physiological processes in the body. Specifically, it can be a loss of the enzyme lactase, which can cause lactose intolerance. Analyzes of the intestinal microbiome have shown associations between the level of magnesium in the diet and the composition of the intestinal microbiota. Magnesium supplementation has been shown to increase the number of bacteria associated with gut health. Limitation of autophagy, i.e. cell repair Autophagy is a cellular process in which cells repair and recycle damaged cellular components. The body's ability to carry out this process decreases with age, which contributes to the accumulation of damaged cellular structures and parts. You can think of it as a kind of cellular debris inside a cell. So you probably understand that it's not exactly an ideal situation. Studies have shown that magnesium can help with this quite well. Low levels of dietary magnesium are associated with reduced autophagy, while magnesium supplementation can promote autophagy. Autophagy eliminates pathological phenomena in cells. Telomere shortening You may have heard of them before. Telomeres are sections of DNA at the ends of chromosomes that shorten each time a cell divides. And so they get shorter with age. When telomeres reach a critical length, cell division stops. The main role of telomeres is to protect the chromosome. This is where magnesium plays an important role. It helps regulate the structure, integrity and function of telomeres as well as an enzyme that prevents telomere shortening. Research has shown that higher magnesium intake will help with longer telomeres. Thanks to magnesium, the telomeres can divide for a longer period of time and the cells live longer thanks to this. Low levels of magnesium in older age will also affect intercellular communication, immunity, stem cells and overall cell division of various tissues or alter cell metabolism. However, it is not always easy to detect magnesium deficiency in the body. The level of magnesium is usually determined by measuring the total level in the blood serum, which reflects only a very small part of the body's magnesium content. Approximately 50-60% of the body's total magnesium content is stored in the bones and the rest is stored in the cells. Only less than 1% of body magnesium is found in serum. Therefore, serum values ​​often do not accurately reflect cellular magnesium status. These may be low even when serum levels are in the appropriate range. Another option for measuring magnesium levels in the body is a blood test, or its amount in the cells. Have you tried Mg 2.0 yet? It is a unique combination of 6 organic forms of magnesium combined with vitamin D for even better absorption. Buy

Learn more

Stress and its benefits

In history they told us about the Bronze or Iron Age. Maybe over time, ours will be labeled as plastic and stressful. Stress is simply a part of modern society. Whether it's high performance demands, fast times, constant trends and changes to the noisy environment of big cities. Despite all the negative aspects that stress brings to a certain extent, it can also be beneficial for the organism. In what and when is stress more of an enemy than a helper? In this article, we will look at the "good stress". In it you will also find practical tips on what to try if you are experiencing acute stress. What is stress and how does it arise? It is a set of physiological and psychological reactions of the body to external or internal stimuli that are perceived as demanding, threatening or exhausting. It arises when the body perceives a situation as a threat or a challenge and activates the so-called "fight or flight" response. If the body is in such a state for a long time, we are talking about chronic stress, which is not beneficial to the body. Its opposite is acute stress, from which some we can extract the benefits. So what can "good stress" do? Improves cognitive functions Maybe you know that feeling in your stomach when you're sitting on a proper merry-go-round. It's also a certain amount of stress on the body, even if you're enjoying the crazy ride. This sensation occurs in response to mild levels of stress and can potentially increase your brain's performance. Mild stress strengthens connections between neurons in the brain, improves memory and attention, and helps you be more productive. A study by scientists at the University of Berkeley reports that in laboratory rats, brief stressful events activated stem cells in their brains. These multiplied into new nerve cells, which after two weeks led to an increase in mental performance. Better brain performance probably explains why some people work better when under stress. These are last minute or tight deadline tasks. You can easily check if you are one of them by observing yourself. Try to evaluate your performance during a day when you experience a higher level of stress at work. You may find that you are more focused and productive than on low-stress days. It helps to avoid infections The fight-or-flight response that occurs during stress is designed to protect you, whether from injury or another threat. Interestingly, low doses of the stress hormone help protect against infections as well. Mild stress stimulates the production of a chemical called interleukins, giving the immune system a quick boost that can protect it from disease, unlike chronic stress, which lowers immunity and increases inflammation. What about those interleukins? It is a group of proteins that play a key role in the regulation of the immune system. They are signaling molecules that enable communication between different types of white blood cells (immune cells) and other cells in the body. Each interleukin has a specific function and purpose, such as promoting the growth and activation of immune cells, coordinating the immune system's response to infection and inflammation, or assisting in the production of antibodies. Increases your mental stamina When we are dealing with a problem or situation, it can be very stressful. Diseases or vaccinations work on the same principle. At first exposure, the body may become confused. But for the second flu in life, the body will already have instructions on what to do and how to do it. It's the same with any other event. Exposure to situations that are not standard teaches the brain to be more resilient in the future. And in that case, the stress made you stronger. But how to best manage such situations? We have a few practical tips for you that you can try right now: Extended exhalations are probably the easiest and fastest help in stressful situations. for quick relief, it is enough if the exhalation is longer than the inhalation. For example , inhale for 4, hold your breath for 7 and exhale for 8. Breath is a great first aid tool because you have it with you everywhere. The second handy breathing exercise is box breathing. During it, there is an inhalation, an exhalation and a 4-second breath hold between them. It looks like this: inhale for 4 beats, hold your breath for 4 beats, exhale for 4 beats and hold your breath for 4 beats. The mindfulness technique will also help with acute stress. It's about redirecting the mind to an object other than ourselves. You can try the 5-4-3-2-1 method . just look around and find: 5 things you see 4 things you can touch 3 things you hear 2 things you feel 1 thing you can taste If it's too complicated at first, try to focus on just one sense, like sight, and find as many objects of the same color as possible. The great thing is that mindfulness can be trained well and is a great helper in stressful situations. The next tip needs a bit of practice, but then you can use this technique anywhere. This is Jacobson's progressive relaxation . It consists in tightening and relaxing the muscles accompanied by inhalation. Usually a breath for 5 beats with a gradual contraction of the selected muscle group from a slight contraction to your maximum. This is followed by gradual relaxation and exhalation. We promised practical examples, so we are sending a video from the organization Don't Let Your Soul Go: https://www.youtube.com/watch?v=6U3C_uhKfUc In addition to the mentioned techniques, you can also try meditation, relaxing music with headphones or herbs and herbal teas. St. John's wort, lemon balm, hops or valerian, which you can find in our Stress Free, have a calming effect. So stress less! Buy

Learn more

Jet lag and adaptation to a new time zone from the point of view of biohacking

How does jet lag occur? Traveling across different time zones presents significant challenges due to the circadian nature of the organism. Especially if you are heading east. When traveling in this direction to the east, one shortens the day, when traveling to the west it lengthens. A shorter day then causes problems with falling asleep. Upon arrival, the body needs to adapt to the new regime. It has established a new routine. The same eating times, activities as at home, only at a new time. Diet is especially important for the rapid adaptation of the organism to the new time zone. Eating according to the new time zone is the best way to reset your "internal clock". Try to imagine that you are on a night flight. How to prepare, what to leave out and what, on the contrary, can help you cope with jet lag more easily? Before departure In order for the organism's adaptation to the new zone to go as smoothly as possible, it is necessary to skip all stimulants in the last 24 hours before the flight and avoid them for at least 48 hours after the flight. This applies to coffee, teas containing caffeine or guarana. Make sure you are properly hydrated before your flight. On the contrary, what should not be missed is the dinner just before the flight. It will be the last meal for the next few hours. The ideal choice is nutritionally quality food. It should include plenty of meat, complex carbohydrates such as rice, potatoes, pasta, quinoa and fresh vegetables. Fast food at the airport is a tempting option, but the food won't fill you up enough and you could be hungry on the plane. 18:30 Put on glasses against blue light! The earlier, the better you will sleep on the plane. Airplane flight Eating during the flight is an unnecessary burden on the body's circadian rhythm. For example, an eight-hour flight with a departure after 19:00 should ideally be managed without food. This makes sense, because in the current time zone, you probably won't be eating a sandwich at two in the morning either. Just a plane flight is an unpleasant situation for the body. Dry filtered air, airborne pathogens, altitude dehydration and later jet lag. There is no need to add poor quality airplane food. What to pack on the plane? ✅ Lots of liquids, at least 2 l, ideally with admixtures of minerals and electrolytes ✅ Sleeping mask ✅ Earplugs or noise canceling headphones ✅ Pillow, neck pillow, anything to support your head Overnight travel brings the opportunity to use the flight to sleep. It would be advisable to sleep for at least the first half of the flight. In the second half of the flight, if you don't sleep, we recommend getting your heart pumping a little and getting your circulation going. You probably don't need to do push-ups in the alley, but a few squats on the toilet will work just the same. And don't forget about continuous stretching during the session. Did you know that a longer stay on a plane can start inflammatory processes in the body? This is because being disconnected from the Earth's magnetic field will increase oxidative stress. So pack some antioxidants, for example vitamin C, on the plane. Upon arrival You must be hungry. And that's okay. It's just good to reach for quality again. Avoid sweets and other temptations that make you eat more unhealthy things. Again, it's a good idea to add fluids. A little exercise will also help. A faster walk or a short run if you are a jogging enthusiast. A cold shower, or at least lukewarm, and a meal with a higher amount of complex carbohydrates, good quality protein and low fat. If you are flying from the Czech Republic to Japan, for example, the need for sleep on the first night probably won't come, because you won't be home until late in the afternoon. So how could such a sample evening look like: ✅ At 19:30 new time at the latest, put on glasses against blue light. ✅ Go to sleep around 11:00 p.m. ✅ About 30 minutes before going to bed, you can take melatonin to start its proper production. ✅ GABA in a dose of about 500 mg or the Sleep product, a unique combination of natural substances for faster falling asleep and better sleep, will also help with falling asleep. ✅ A sleeping mask and earplugs will ensure darkness and silence. The first morning and the first hour after waking up will also be very important! You might wake up a little groggy. And that's okay. It's because of the melatonin level. It is important to adjust the circadian clock: ✅ Replenish minerals as soon as possible after waking up. A pinch of salt will help with this. Also creatine or glycine. ✅ Expose yourself to daylight. Take, for example, a 15-minute walk outside. ✅ Cold shower for 2-3 minutes. ✅ Breakfast, preferably without coffee. Substances that will help manage jet lag GABA Gamma-aminobutyric acid is the main inhibitory neurotransmitter in the central nervous system. It is well known that GABA promotes relaxation, falling asleep and sleep by activating GABA receptors in the brain. These are involved in reducing the excitability of nerve signals. GABA is able to induce relaxation, reduce anxiety and strengthen immunity in stressful conditions. CBD Phytocannabinoids such as CBD bind to cannabinoid receptors and affect the endocannabinoid system in the human body. Their action promotes relaxation and relaxation of the central nervous system, helps suppress pain and the perception of negative emotions. At the same time, it is a valid helper for athletes in states of great mental strain, such as competitions and demanding training periods. Sleep The combination of natural substances will calm you down and prepare you for a natural sleep. It has mild sedative effects and will allow you to fall asleep faster, even outside of your bed. Buy Buy Buy Buy

Learn more

6 tips to naturally support digestion

Summer is in full swing and while it's great to sit with friends over good food, sometimes it can be difficult for our digestion. Heavy and fatty meals, as well as large fluctuations in blood glucose, can affect our digestion and the amount of energy during the day. Why is stable glucose important? Blood glucose levels naturally rise after a meal. How much depends on the amount of carbohydrates in the food we ate. When glucose levels rise, insulin, an important hormone that distributes glucose from the blood into cells for immediate use or storage, is flushed out. Excessive and frequent glucose fluctuations can contribute to overall inflammation in the body, mood and energy fluctuations, inefficient metabolism and the development of possible long-term health problems . So how do you keep your glucose levels at healthy levels? 1. Tip: Move after eating A simple walk immediately after a meal for 15 minutes reduces the rise in blood glucose. In this way, you will avoid a drop in energy and support a healthy metabolic reaction. 2. Tip: Think about the order The order of macronutrients consumed affects glucose levels. For better glycemic control, consume fiber and protein first, followed by carbohydrates and fats. It is ideal to start the meal with a vegetable appetizer. 3. Tip: Sleep pink Sleep plays an integral role in metabolic homeostasis. If you don't sleep well, you significantly reduce glucose tolerance (ability to use carbohydrates) and insulin sensitivity. This means that lack of sleep impairs glucose metabolism (the body's ability to deal with carbohydrates). 4. Tip: End of midnight snacks Glucose and sleep seem to influence each other. Sleep affects glucose levels, and conversely, poor body control of blood glucose at night affects sleep. It is important to stabilize glucose levels before going to bed and limit evening "snacks". We know it's not an easy task. 5. Tip: Say NO to ultra-processed foods These foods, which often contain large amounts of sugar, fat and other substances, can raise blood glucose levels very significantly and negatively affect metabolic health in the long term. Bet on real staples. How do you recognize them? They are the ones that do not have an endless list of ingredients in their composition. This includes fruits, vegetables, legumes, kernels of unroasted and unsalted nuts, seeds and whole grains, but also foods of animal origin, which ideally come from organic farming. 6. Tip: Hardening? Correct timing is the key to success Do not strain immediately before and after meals. Exposure to cold activates the sympathetic nervous system. This reaction triggers a flush of norepinephrine, which can disrupt the secretion of digestive enzymes. This can lead to insufficient digestion of food, bloating and malabsorption of nutrients. And a bonus tip at the end! Natural substances and enzymes to support digestion. Digest is a natural food supplement that supports digestion and healthy metabolism even after heavy meals rich in carbohydrates, proteins and fats. Don't you like the feeling of a heavy stomach after a meal? The digest is designed to optimize digestion, speed up the breakdown of nutrients and thus promote a harmonious balance in your digestive tract. For a good feeling after a meal, without bloating, a heavy stomach and a sharp drop in energy after a carbohydrate load. I want to improve digestion

Learn more

How does alcohol affect physiological processes in the body?

Have you ever wondered what happens to your body when you have a beer or a shot? What processes does alcohol trigger in the body? Let's see what alcohol affects in the body and what awaits you when it returns home from the summer garden. You wake up more tired after drinking alcohol Although alcohol may make you sleep better, the quality of your sleep will be worse. Why? This is because alcohol binds to the same places in the brain as the neurotransmitter GABA, which is responsible for relaxation and inducing well-being. Thanks to this, you will fall asleep faster after drinking alcohol, but the quality of your sleep will decrease. The ratio of REM sleep during the night, which optimally makes up 20-25% of the sleep cycle, will also decrease. It is a phase when the brain is very active, memories are sorted, emotions are processed. This also explains why you wake up more tired in the morning. Extra pounds and calories You probably know that alcohol contains empty calories. The amount varies from drink to drink. Alcohol also temporarily increases the appetite for sweet and fatty foods. It also affects hormones responsible for appetite, such as ghrelin and leptin. Leptin regulates the feeling of satiety, and ghrelin, on the other hand, tells the brain that the body is hungry. And that's why you may simply have more cravings for no apparent reason when consuming alcohol. If there is an imbalance between these hormones, they can affect changes in weight. Which alcohol has the least calories? The winner is wine. You will find the most sugar in various drinks with fruit juices. Watch out for you. Digestive problems and disturbance of the intestinal microflora In addition to short-term nausea, alcohol also affects the overall intestinal microflora. It can thus cause not only digestive problems, but also depression and mood deterioration due to the confirmed gut-brain connection during prolonged use. During the breakdown of ethanol, substances are also created that overacidify the organism. A change in pH in the body can wreak havoc, especially when it comes to metabolic processes. The trio of minerals magnesium, zinc and selenium helps to raise the pH and easily copes with the problem. Did you know that 400 times more information travels from the intestines to the brain than from the brain to the intestines? A burden on the liver Alcohol is the biggest burden on the liver, which is dedicated to the overall detoxification of the organism. This is done with the help of enzymes. But the liver can only process a small amount of alcohol at a time. Its excess then circulates throughout the body. So the decomposition process repeats itself until the body breaks down all the alcohol. This can take a few hours, or even a whole day. During this time, the body prefers to break down alcohol, as it tries to get rid of toxins as quickly as possible. So how to help the liver with regeneration after the party? It is useful to add antioxidants such as vitamin C and E, B complex, which supports detoxification, but also magnesium, omega 3 fatty acids and the previously mentioned selenium and zinc. After four weeks without alcohol, fatty tissue in the liver is reduced by up to 20%. Hormone imbalance We have already discussed the hormones leptin and ghrelin. But these are not the only hormones that alcohol affects. For example, alcohol can affect testosterone production both in the long term and in the short term. Even occasional drinking can disrupt testosterone production in men by negatively affecting the pituitary gland and hypothalamus. One study shows that testosterone can drop dramatically just 30 minutes after consumption. Another hormone that alcohol has a direct effect on is dopamine. Alcohol increases the production of dopamine and thus induces a feeling of happiness, joy, relaxation and slows down the flow of nerve impulses in the brain. This is why our judgment is a bit skewed when we drink. And then there's the classic hangover, but I'll look into that next time. If you want to eliminate a hangover as much as possible, you can try our Hangover. In the e-shop, you will also find the supplements mentioned in the article, such as omega 3 , magnesium , liposomal vitamin C or Daily Essentials , thanks to which you will replenish all the necessary essential vitamins and minerals not only after a night of excess. Display Display Display

Learn more

Omega 3 - Everything you need to know

There are countless articles on the subject of omega 3 fatty acids. Google alone finds over three million of them in half a second. However, not all articles will provide answers to your questions. We have put together an article that we once wished we had read. An article that contains all the comprehensive information you need to know about omega 3. An article that will stop you fumbling. What are omega 3 fatty acids? Omega 3 belongs to the group of polyunsaturated fatty acids (PUFA), referred to as essential fatty acids. They earned the label essential because the body cannot produce them on its own in most cases. We have to get them from our diet. What do omega 3 contain? There are several different omega 3s, but most scientific research focuses on only three types. The main omega 3 fatty acids are: - α-linolenic acid (ALA) - eicosapentaenoic acid (EPA) - docosahexaenoic acid (DHA) Of the three, EPA and DHA are the most important for our health. Alpha-linolenic acid (ALA) is used in the body to produce EPA and DHA. However, the rate of conversion of ALA to EPA is poor, so it is necessary to increase the intake of EPA and DHA. So if you care about your health (and we believe you do if you're reading these lines), focus on getting EPA and DHA directly from food and supplements. It is the only practical way to increase the level of omega 3 fatty acids in the body. Why are omega 3 important? Have you heard the saying: You are what you eat? This also applies to cell membranes. DHA and EPA fatty acids are an essential component of the cell membranes of all cells in the body. When we consume dietary fat, much of it goes directly to building these membranes. In the absence of DHA and EPA in the diet, our cell membranes are made of saturated fatty acids and omega 6 fatty acids. This results in stiffer, less permeable cell membranes and slowed cell function. Sounds like a big deal, don't you think? Indeed it is! The ratio of omega 6 to omega 3 is important The difference between omega 6 and omega 3 is the chemical bond and the location of the first double bond. This is not a big deal for most people. The important point is that they are metabolically and functionally distinct and often have important opposing physiological effects. Therefore, their balance in the diet is important. Currently, the intake of saturated fat and omega 6 is several times higher than the intake of omega 3, and this may contribute to higher levels of inflammatory molecules in the body. [1] But this does not mean that saturated and omega 6 fatty acids are bad. All these fats perform necessary functions in the body. However, their consumed ratio is important. It is estimated that in today's modern Western diet the ratio of ω-6 to ω-3 ranges from 10:1 to 20:1. The key to healthy cells is an ideal ratio between 4:1 and 2:1. The real ratio is indeed alarming. It is thought to be linked to the global increase in diseases related to chronic inflammation and promotes the rise of diseases including cancer, cardiovascular, inflammatory and autoimmune diseases. [2] [3] The effects of omega 3 Omega 3 for brain and cognitive function Omega 3 fatty acid consumption is one of the best-studied interactions between food and brain development. Docosahexaenoic acid (DHA) is essential for synaptic transmission and cognitive abilities. [4] Systematic reviews and randomized trials have found that omega 3 can positively influence memory, memory function and reaction times in young adults. [5] [6] Omega 3 and athletes Omega-3 fatty acids have been shown to affect the health and performance of athletes in many ways, including reducing inflammation, improving muscle recovery, and protecting brain health and function. A recent randomized, double-blind, placebo-controlled trial in healthy young men showed that DHA and EPA supplementation can accelerate recovery by reducing the time it takes for muscles to adapt to a training stimulus. Subjects who supplemented with DHA and EPA returned to maximal strength and full range of motion more quickly, and also reported less muscle soreness after exercise. [7] In a systematic review of studies from 2020, omega 3 supplementation was shown to have a positive effect on aspects of sports performance such as reaction speed and better functionality of the cardiovascular system, including blood flow and oxygen consumption. [8] EPA and DHA can influence many aspects of human physiology and metabolism, and this can in turn influence outcomes related to athletic performance, recovery, convalescence, illness and injury. For most athletes, general recommendations should include EPA and DHA at about 1 to 2 g/day at a EPA:DHA ratio of 2:1. Other benefits Joint health EPA and DHA promote a healthy response to inflammation, which can positively impact swelling, pain and stiffness associated with joint problems. Omega 3s may be mildly helpful in relieving the symptoms of rheumatoid arthritis. [9] Improved triglyceride levels Triglycerides are a type of fat found in human blood. They are a vital indicator of heart health. Excessive levels of triglycerides can increase the risk of heart disease. High doses of DHA and EPA can have a positive effect on triglyceride levels. [10] Skin health and UV protection Omega 3 fatty acids show the potential to protect the skin from the harmful effects of UV radiation and reduce UV-induced inflammation. [11] Omega 3 in food The best sources of α-linolenic acid (ALA) are: - flax seeds - chia seeds - hemp seeds - walnuts However, if you recall, the body is inefficient at converting ALA to EPA and DHA. For this reason, it is necessary to consume EPA and DHA directly from fish and seafood. The best sources are: - mackerel - herring - salmon - anchovies - sardines - seafood and seaweed However, Czechs are not known for their large consumption of fish and seafood. Therefore, we recommend increasing your intake of omega 3 through food supplements. High-quality food supplements with fish oil such as Flow Omega 3 can be an excellent source of omega 3 fatty acid supplementation. Which foods are better to avoid? Foods high in omega 6 - vegetable oils (sunflower oil, corn oil, margarine) - industrially processed products (frozen ready meals) - fried meals - sausages - salty snacks (corn flakes, chips) How to take omega 3? Fish oil is best absorbed by the body when consumed with food. The time of day doesn't seem to matter. Therefore, you can supplement omega 3 with any food that suits your lifestyle. General guidelines recommend a dose of 250 mg per day, but most research shows that higher intakes provide greater benefits. The intake of omega 3 fatty acids should range from 1,000 to 2,000 mg per day. It is recommended not to exceed 3000 mg of omega 3 per day. Conclusion Now you know why omega 3 is so important. Healthy cells and a well-functioning brain require the consumption of the right essential fatty acids in an optimally balanced ratio. So if you want optimal body performance and a fast and sharp brain, limit foods with a high omega 6 content and supplement with more omega 3.

Learn more

The science behind Longevity - A look at aging

Understanding Aging One of the challenges for scientists in recent years has been gaining a clearer understanding of the fundamental biological changes that accompany aging. There is no single primary cause of aging or unified "theory of aging" that accounts for all the features of biological aging. Aging is not caused by just one type of cellular damage or by too little/too much of one molecule. Aging itself cannot be influenced simply by focusing on one thing. Rather, it involves a multitude of factors that accelerate and/or decelerate biological processes later in life. Among the most common perspectives on aging are those related to free radicals, mitochondria, and gene expression (subcellular level), cellular senescence and stem cell perspectives (cellular level), and neuroendocrine and immune perspectives (systemic level). The aging process entails understanding the molecular, genetic, and cellular mechanisms that make aging a risk factor for the development of chronic diseases. It is becoming evident that targeted focus on healthier aging will slow and/or reduce the incidence of many diseases and improve health. Healthier Aging Healthier aging = successful aging. The concept of healthy and successful aging primarily focuses on living a longer, fulfilling, and healthy life. There are two fundamental mechanisms that demonstrably lead to healthier aging. Physical activity Caloric restriction (Intermittent fasting, time-restricted eating) Both of these activities provide benefits for healthy aging. Their specific biological mechanisms cause dramatic changes in metabolic functions, cellular signaling, mitochondrial functions, and gene expression (how our cells express themselves). Athletes can serve as an excellent example of gene expression. Comparing long-distance runners and bodybuilders, their gene expression will vary depending on their training. Endurance training and strength training activate and deactivate different genes. As a result, the body can adapt its responses to better suit specific habits and environmental challenges. It makes much more sense to activate and deactivate a set of genes that promote increased endurance in a runner or cyclist. In a regular gym-goer, it makes more sense to adjust gene expression to increase muscle size and strength (endurance is less important). Each person is made up of trillions of cells. Each of these cells has many tasks, such as repairing damage, producing energy, fighting pathogens, and responding to hormonal signals. In these cells, millions of cellular processes occur every second, ensuring the functioning of the entire biological system. The human body is incredibly complex and comprehensive, constantly trying to adapt to external and internal changing conditions. However, each cell has its lifespan, influenced by the interaction of genetic, environmental, behavioral, and social factors and lifestyle. These interactions and changes over time can cause excessive damage and premature cell death, leading to inadequate or excessive gene expression. Cellular damage occurs one way or another because it is a normal part of metabolism. When we are younger, cells do a better job of repairing this damage. As we age, some damage cannot be repaired. When damaged cells replace themselves, the damage is transferred to new cells. This accumulated damage affects cell function, including their ability to self-repair. Therefore, healthier aging requires creating an internal "friendly" environment that allows cells to perform their best. That is the goal that supports functional cellular mechanisms for proper metabolism, repair, and energy production. Healthier aging does not necessarily mean longer lifespan, but rather "extending the part of life spent in health." And that is our primary goal. Science and Formulation To date, science has uncovered several fundamental mechanisms of healthy aging. In formulating Longevity, we focused on these mechanisms and aimed to mimic this effect. Among other things, we targeted substances that mimic the effect of caloric restriction and exercise. Our goal was to incorporate some of the functional cellular benefits into the dietary supplement. Don't worry! No pill can replace real physical activity and healthy habits. It doesn't mean you can stop moving and eat unhealthy foods. It means we designed this product to work synergistically with other healthy habits and support healthier aging. Although there is no unified theory of aging, all perspectives on aging have one thing in common: cell damage and dysfunction are at the core of aging. After all, when we talk about anything related to aging, we're actually talking about cellular degeneration. Many signs of aging are often symptoms of failing cellular mechanisms or mitochondrial damage. But... We cannot overlook gene expression either (think of athletes, for example). Dysfunction in gene expression can increase the accumulation of damage, and the accumulation of damage can disrupt gene expression. It's almost a devilish cycle that accelerates over time and causes more problems than the organism can repair. The good news is that this cycle can be interrupted at several points, with functional support for one molecule, pathway, or process improving the others. Even better news is that we don't have to do just one thing. We can support many simultaneously, multiplying the benefits. That's our comprehensive approach to healthy aging. While the market is flooded with products targeting aging, they tend to focus more on some narrow aspect of cellular energy, repair, or metabolism. Our approach focuses on the entire system and on a wide range of processes needed to support healthier, more functional, and more efficient cells. When our team formulated Longevity, we focused on strengthening a range of cellular biomolecules, pathways, and processes. We tried to turn metaphorical small pieces into a grand work of healthy aging. But which piece is the most important for cells to function at their highest level? The answer is NAD. Let's start here.   Formation and Optimization of NAD+ NAD, or nicotinamide adenine dinucleotide, is a critical molecule for healthy aging. Numerous studies have shown that cellular levels of NAD decline during chronological aging. By middle age, our NAD levels drop to half the level of our youth. This decline plays a crucial role in the development of metabolic dysfunctions and age-related diseases. Increasing NAD+ levels improves some metabolic functions, has the ability to reverse mitochondrial dysfunction, and extends lifespan.   It seems that there is a vicious cycle in which molecular mechanisms involved in the aging process, such as oxidative stress, DNA damage, and inflammation, lead to a decline in NAD in tissues, which subsequently worsens the processes that caused its decline in the first place. (Another devilish cycle.) A very important piece of the puzzle of healthy aging is undoubtedly the formation of NAD+. This molecule is present in all living cells, so it's no surprise that many bodily functions can only operate in conjunction with NAD+. Therefore, there are several ways and pathways in the body to produce NAD+. By middle age, our NAD+ levels drop to half the level of our youth. The most direct pathway to NAD+ formation is through a substance called NR (Nicotinamide Riboside). NR is metabolized in the body and converted into NAD+. Since NAD+ is such a crucial molecule for the body, there are other processes by which NAD+ is formed. It is synthesized via the De Novo pathway, which utilizes the amino acid L-Tryptophan, Preiss-Handler, and Salvage pathways using Niacin (vitamin B3). Various tissues in the body utilize these three pathways to meet the almost unceasing demand for NAD+. Therefore, we formulated the composition with a view to supporting all three pathways. When scientists investigated why NAD levels decline with age, they found an enzyme called CD38, whose levels increase during aging. This enzyme causes the breakdown of NAD. The good news is that CD38 can be slowed down. Apigenin and quercetin, substances found in fruits and vegetables, act as inhibitors of CD38 and thus slow down its activity. In this way, they increase and optimize the amount of NAD+ in the body. The first piece in supporting cells against aging. Formation and Optimization of NAD+ NR L-Tryptophan Niacin (vitamin B3) Apigenin (CD38 enzyme inhibitor) Quercetin (CD38 enzyme inhibitor) But let's go one step further. Mitochondria and Energy Metabolism Mitochondria are among the most important organelles in cells, participating in a wide range of processes crucial to cellular function. The key function of mitochondria is to generate cellular energy. Mitochondria host the major processes that enable energy production from nutrients. This "cellular power plant" produces 99% of energy (in the form of ATP). Cellular metabolism converts carbohydrates, fats, and proteins into energy. Each of these macronutrients has its own cellular energy pathway (glycolysis, beta-oxidation, citric acid cycle, oxidative phosphorylation) where cellular energy production occurs. (All of these pathways depend on NAD). However, they also need other substances (cofactors) to contribute to the production. Without them, energy production could not proceed. All B vitamins except folic acid are involved in at least one and often several steps of the cellular energy production system. Substances such as alpha-lipoic acid, cysteine, and CoQ10 also participate in energy production in one of the steps of metabolism or support mitochondrial health. Supporting mitochondria, energy metabolism, and ATP production is another piece for healthy aging. Support for Mitochondria and Energy Metabolism B vitamin complex Alpha-lipoic acid N-acetylcysteine CoQ10 Mitochondrial biogenesis Mitochondrial biogenesis is an important cellular process that creates new mitochondria. One of the best physiological conditions that lead to an increase in mitochondrial mass (formation of new mitochondria) is physical activity. Endurance exercise stimulates molecular pathways (PGC-1α, PGC-1β, AMPK, CaMK, ERK1/2, p38MAPK and others) that are the basis of cellular processes supporting mitochondrial biogenesis. This important cellular process is essentially part of the adaptive cellular response to the metabolic demands of the organism. Simply put, it is an adaptation to increased energy expenditure. These "sensors" for nutrient availability regulate energy balance and play key roles in stimulating fat burning and fatty acid oxidation. Cells thus compensate for increased energy demands. This adaptive response leads to greater mitochondrial formation, thereby increasing the cell's capacity to produce ATP. Healthier aging requires a comprehensive scientific approach focused on the interacting network of molecules, pathways, and processes that enable cells to perform at their best. The quantity and functionality of mitochondria have a fundamental impact on aging manifestations. It is well known that mitochondria are particularly affected by diseases and contribute to the aging process itself. Aging is therefore accompanied by a decline in mitochondrial function, and this decline may also contribute to the decline in organ functions. (Another, already the third, devilish cycle.) Not only mitochondrial health, but also mitochondrial biogenesis, is the answer to healthier aging. When we mentioned earlier that Longevity mimics the effect of exercise, we specifically referred to mitochondrial biogenesis. Specifically, the molecular pathways that trigger mitochondrial biogenesis. Scientific studies confirm that certain substances and plant extracts have the ability to stimulate these pathways and contribute to mitochondrial biogenesis. Another piece in supporting a more robust aging system. Mitochondrial biogenesis and stimulation of molecular pathways Gynostemma pentaphyllum extract Resveratrol Pterostilbene Rutin PQQ Apigenin Alpha-lipoic acid CoQ10 Closely related to metabolic regulators is another group of enzymes... Increase in sirtuin activity (longevity genes) Sirtuins (Silent information regulators), also sometimes referred to as longevity genes, are a group of enzymes that regulate a wide range of cellular processes, particularly those related to cellular energetics and homeostasis. It is assumed that sirtuins play a key role during the cellular response to various stresses (caloric restriction, ketogenic diet, exercise, sauna) and are crucial for cellular metabolism. Sirtuins adjust cellular metabolism based on nutrient availability and regulate many metabolic functions, including DNA repair, genome stability, inflammatory reactions, and mitochondrial functions. Sirtuins activate and deactivate many genes involved in health and lifespan extension. Sirtuins, for example, regulate signaling pathways such as PGC-1α. At this point, it should come as no surprise that a proper lifestyle, including physical activity and a healthy diet, can influence health through increased sirtuin activity. Substances that act as sirtuin activators were another piece that contributed to our understanding of healthy aging. Support for longevity gene activity (sirtuins) Resveratrol Pterostilbene Cocoa extract PQQ Quercetin Rutin Support for antioxidant protection Mitochondria, the main energy "powerhouses" in cells, produce reactive oxygen species (ROS) as a byproduct during energy production. ROS are often referred to as harmful molecules that cause aging and cell damage. Yes, if the amount of ROS is not kept in check, their effect damages cells and mitochondria, contributing to aging. Unhealthy lifestyle, lack of sleep, and stress seem to be risk factors contributing to excessive production of reactive oxygen species. However, ROS are also an important part of the body's signaling pathways. It is well researched that exercise-induced increase in ROS production in skeletal muscle plays a desired role in skeletal muscle adaptation to endurance training. Exercise contributes to the production of reactive oxygen species, but it is unlikely to result in a level of oxidative stress that is harmful to health. Exercise is thus a positive type of stress, which, not only through ROS, triggers healthy cellular and mitochondrial adaptations. Therefore, our goal is not to prevent mitochondria from producing ROS or to try to suppress them with a large amount of antioxidants. A better approach is to help mitochondria help themselves. These substances support the body's own antioxidant processes, reactions, and the production of enzymes that the body uses to protect against reactive oxygen species. Supporting Antioxidant Protection PQQ Quercetin Rutin Alpha-Lipoic Acid CoQ10 Zinc Cellular Aging and Telomere Shortening Inhibition As mentioned earlier, our cells adjust their behavior throughout life depending on the state of nutrients and stress (gene expression). When we are younger, our cells do a better job of repairing damage. With increasing age, this process weakens, and damage can be transferred to new cells. As cells continue to divide, the ends of DNA (telomeres) gradually shorten. When telomeres reach their critical length, genetic information is lost, which can trigger cell self-destruction. An enzyme called telomerase slows down this shortening and helps with the constant renewal of telomeres. Gradual telomere shortening is considered one of the molecular mechanisms of organismal aging. Telomere shortening also reduces sirtuin activity. Conversely, increasing sirtuin activity stabilizes telomeres and improves conditions dependent on telomerase. As mentioned earlier, when we are younger, cells do a better job of repairing this damage. As we age, some damage remains unrepaired. When damaged cells replace themselves, the damage is transferred to new cells. This accumulated damage affects cell function, including their ability to repair themselves. If a sufficient number of cells are damaged, it reduces tissue performance, leading over time to visible and invisible aspects of unhealthy aging. Thanks to longer and more stable telomeres, it is possible to prevent the mass aging of cells and prevent the onset of a variety of diseases. Supporting Telomerase Against Telomere Shortening Centella Asiatica Extract Vitamin D3 Selenium Vitamin B9 Senescent (Aging) Cells and Immunity Support When cells reach a stage where they can no longer divide, they become senescent cells. These are normally destroyed through a programmed process called apoptosis and removed by the immune system. However, with age, the immune system weakens, and a growing number of senescent cells escape this process and begin to accumulate in all tissues of the body. Their presence causes many problems because they release pro-inflammatory substances that cause chronic inflammation and damage to surrounding healthy cells and tissues. This accelerates aging. Just like all the biological systems described above are negatively affected by aging, our immune system also begins to weaken and fail in later life. As it turns out, senescent cells intensely interact with the immune system, and enhancing immune system performance appears to be a suitable long-term approach to dealing with senescent cells. Therefore, its support is the final piece in the whole picture of healthy aging. Supporting the Immune System and Eliminating Senescent Cells Rutin Quercetin Vitamin D Zinc Selenium Cocoa Extract Healthy Aging Within Reach You now know the mechanisms that guided us in formulating Longevity. Our goal was to focus on comprehensive support for the body and all its interacting molecules, signaling pathways, and processes that positively influence the fundamental cellular mechanisms of aging and are an important part of healthy and successful aging, allowing you to live life to the fullest. P.S. And magnesium? It cannot be omitted. There is another important cofactor for energy production, and that is magnesium. Good observation, it's not in the composition. And no, we didn't forget to incorporate it into the formulation. We are aware that this is a small gap in an otherwise completely complex product for healthy aging, but it has its reasons. One of them is that just 50 mg of elemental magnesium added to the composition requires about 350 mg of magnesium bisglycinate. Such an amount would already require consuming 5 capsules instead of the current 4. The second reason, and it's not a marketing gimmick (aging isn't interested in marketing), is that we already have a product with magnesium. The body needs more than 50 mg of elemental magnesium per day, so we have created our own formulation that contains 6 forms of magnesium for perfect absorption and saturation of every tissue in the body. We are firmly convinced that you will benefit from supplementing additional magnesium. Not only physically but also cognitively.

Learn more